Hamsika took Carnatic music training from her father Shri. S. Balachandran and Guru Smt. Kalyani Mani, Shri. Chandrashekar Bhagavathar. She is trained in Hindustani music from Gurus, Smt. Veena Deshmane, Late Pandit Pheroze Dastoor, Shri. Arvind Apte, Shri. Gautam Mukherjee and Shri. Vinay Pathak.
Director Vidhu Vinod Chopra gave her a chance for the song Chanda Re from Eklavya in 2007, much liked by the audience. Her song Chammak Challo with Akon from the movie Ra.One released in 2011 music given by Vishal-Shekhar and performed by Kareena Kapoor and Shahrukh Khan gave her a new rank in Bollywood, followed by the song One Two Three Four, from Chennai Express in 2013, with Vishal-Shekhar again.